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Scientific article
English

Aryl Hydrocarbon Receptor Activation in Acne Vulgaris Skin: A Case Series from the Region of Naples, Italy

Published inDermatology, vol. 231, no. 4, p. 334-338
Publication date2015
Abstract

Dioxins are persistent organic pollutants present in the environment. They exert their biological effects by binding to an intracellular receptor, the aryl hydrocarbon receptor (AhR). Activation of AhR leads to the induction of cytochrome p450 1A1 (CYP1A1). Expression of CYP1A1 in human skin is a key marker for AhR activation, and it may induce comedogenesis resulting in acne-like lesions known as chloracne/metabolising acquired dioxin-induced skin hamartomas (MADISH). The contribution of this pathway in patients seen in a busy acne clinic is unknown.

Keywords
  • Aryl hydrocarbon receptor
  • Acne
  • Dioxin
  • Smoking
  • CYP1A1
  • Chloracne
  • Metabolising acquired dioxin-induced skin hamartomas
Citation (ISO format)
FABBROCINI, Gabriella et al. Aryl Hydrocarbon Receptor Activation in Acne Vulgaris Skin: A Case Series from the Region of Naples, Italy. In: Dermatology, 2015, vol. 231, n° 4, p. 334–338. doi: 10.1159/000439402
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Article (Accepted version)
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Identifiers
ISSN of the journal1018-8665
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