UNIGE document Scientific Article
previous document  unige:83772  next document
add to browser collection

Centrosomes in spindle organization and chromosome segregation: a mechanistic view

Published in Chromosome Research. 2016, vol. 24, no. 1, p. 19-34
Abstract Centrosomes are complex structures, which are embedded into the opposite poles of the mitotic spindle of most animals, acting as microtubule organizing centres. Surprisingly, in several biological systems, such as flies, chicken, or human cells, centrosomes are not essential for cell division. Nonetheless, they ensure faithful chromosome segregation. Moreover, mis-functioning centrosomes can act in a dominant-negative manner, resulting in erroneous mitotic progression. Here, I review the mechanisms by which centrosomes contribute to proper spindle organization and faithful chromosome segregation under physiological conditions and discuss how errors in centrosome function impair transmission of the genomic material in a pathological setting.
Keywords Bipolar spindleMitosisChromosomal instabilitySpindle orientationBipolar spindle assembly
PMID: 26643311
Full text
Article (Published version) (964 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Groupe Meraldi Patrick (physiologie cellulaire et métabolisme) (922)
(ISO format)
MERALDI, Patrick. Centrosomes in spindle organization and chromosome segregation: a mechanistic view. In: Chromosome Research, 2016, vol. 24, n° 1, p. 19-34. https://archive-ouverte.unige.ch/unige:83772

150 hits

0 download


Deposited on : 2016-05-23

Export document
Format :
Citation style :