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Title

Centrosomes in spindle organization and chromosome segregation: a mechanistic view

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Published in Chromosome Research. 2016, vol. 24, no. 1, p. 19-34
Abstract Centrosomes are complex structures, which are embedded into the opposite poles of the mitotic spindle of most animals, acting as microtubule organizing centres. Surprisingly, in several biological systems, such as flies, chicken, or human cells, centrosomes are not essential for cell division. Nonetheless, they ensure faithful chromosome segregation. Moreover, mis-functioning centrosomes can act in a dominant-negative manner, resulting in erroneous mitotic progression. Here, I review the mechanisms by which centrosomes contribute to proper spindle organization and faithful chromosome segregation under physiological conditions and discuss how errors in centrosome function impair transmission of the genomic material in a pathological setting.
Keywords Bipolar spindleMitosisChromosomal instabilitySpindle orientationBipolar spindle assembly
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PMID: 26643311
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Research group Groupe Meraldi Patrick (physiologie cellulaire et métabolisme) (922)
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MERALDI, Patrick. Centrosomes in spindle organization and chromosome segregation: a mechanistic view. In: Chromosome Research, 2016, vol. 24, n° 1, p. 19-34. https://archive-ouverte.unige.ch/unige:83772

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Deposited on : 2016-05-23

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