en
Scientific article
English

The lung communication network

Published inCellular and molecular life sciences, vol. 72, no. 15, p. 2793-2808
Publication date2015
Abstract

The different types of cells in the lung, from the conducting airway epithelium to the alveolar epithelium and the pulmonary vasculature, are interconnected by gap junctions. The specific profile of gap junction proteins, the connexins, expressed in these different cell types forms compartments of intercellular communication that can be further shaped by the release of extracellular nucleotides via pannexin1 channels. In this review, we focus on the physiology of connexins and pannexins and describe how this lung communication network modulates lung function and host defenses in conductive and respiratory airways.

Keywords
  • Animals
  • Cell Communication/physiology
  • Connexins/metabolism
  • Gap Junctions/metabolism/physiology
  • Humans
  • Lung/metabolism/physiology
  • Respiratory Mucosa/metabolism/physiology
  • Signal Transduction/physiology
Citation (ISO format)
LOSA, Davide, CHANSON, Marc. The lung communication network. In: Cellular and molecular life sciences, 2015, vol. 72, n° 15, p. 2793–2808. doi: 10.1007/s00018-015-1960-9
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Article (Published version)
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Identifiers
ISSN of the journal1420-682X
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