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The lung communication network

Published in Cellular and Molecular Life Sciences. 2015, vol. 72, no. 15, p. 2793-2808
Abstract The different types of cells in the lung, from the conducting airway epithelium to the alveolar epithelium and the pulmonary vasculature, are interconnected by gap junctions. The specific profile of gap junction proteins, the connexins, expressed in these different cell types forms compartments of intercellular communication that can be further shaped by the release of extracellular nucleotides via pannexin1 channels. In this review, we focus on the physiology of connexins and pannexins and describe how this lung communication network modulates lung function and host defenses in conductive and respiratory airways.
Keywords AnimalsCell Communication/physiologyConnexins/metabolismGap Junctions/metabolism/physiologyHumansLung/metabolism/physiologyRespiratory Mucosa/metabolism/physiologySignal Transduction/physiology
PMID: 26100513
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Research group Mucoviscidose et jonctions GAP (229)
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LOSA, Davide, CHANSON, Marc. The lung communication network. In: Cellular and Molecular Life Sciences, 2015, vol. 72, n° 15, p. 2793-2808. https://archive-ouverte.unige.ch/unige:83567

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Deposited on : 2016-05-09

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