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Neuronal specificity of the α7 nicotinic acetylcholine receptor promoter develops during morphogenesis of the central nervous system

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Published in EMBO Journal. 1992, vol. 11, no. 12, p. 4529-4538
Abstract A transient transfection assay has been developed to analyse promoter activity in neuronal cells freshly dissociated from the chick central nervous system. The assay enabled us to identify cis-acting regulatory elements within the 5'-flanking region of the alpha 7 nicotinic acetylcholine receptor gene. In differentiated retina, regulatory elements direct reporter gene expression to a small subset of neurons which has been identified as ganglion cells, i.e. to the population of neurons in which alpha 7 transcripts were localized by in situ hybridization. However, these promoter elements exhibit ubiquitous activity in undifferentiated neural cells and in mesodermal stem cells. Our study supports the idea that alpha 7 regulatory elements acquire their neuronal specificity in the course of embryogenesis.
Keywords Acetylcholine receptorNeurogenesisNeuron transfectionNeuronal promoter
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MATTER-SADZINSKI, Lidia et al. Neuronal specificity of the α7 nicotinic acetylcholine receptor promoter develops during morphogenesis of the central nervous system. In: EMBO Journal, 1992, vol. 11, n° 12, p. 4529-4538. https://archive-ouverte.unige.ch/unige:83300

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Deposited on : 2016-04-21

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