• Home
  1. Home
  2. Patent Literature Review of Ophthalmic Inserts
Scientific article
English

Patent Literature Review of Ophthalmic Inserts

Contributors

Gurtler, Florian; Gurny, Robert

Published in

Drug development and industrial pharmacy, vol. 21, no. 1, p. 1-18

Publication date

1995

Abstract

In the area of topical ocular administration, important efforts concern the design and the conception of new ophthalmic drug delivery systems able to prolong the residence time. The use of inserts, which are solid devices to be placed in the cul-the-sac or on the cornea represents one of the possibilities to reach increased residence time. These solid ophthalmic devices present the advantage of avoiding a pulsed release due to multiple applications. In the scientific literature, patents are often not mentioned resource and this remark is particularly true in the case of ophthalmic inserts: there is no review yet describing patented ophthalmic inserts. Thus the review presented herein essentially takes into account patented ophthalmic inserts. The solid ophthalmic devices are classified into three major categories based upon their solubility behavior: the insoluble, the soluble and the bioerodible inserts. When necessary, these groups are subdivided into more specific sub-groups. The discussion essentially takes into account the design, the conception, the release mechanisms, the in vivo and in vitro assays, the limitations, and the therapeutic rationale for their use.

Keywords

  • Ophthalmic Formulations
  • Sustained Release
  • Inserts
  • Review

UNIGE affiliation entities

Citation (ISO format)

GURTLER, Florian, GURNY, Robert. Patent Literature Review of Ophthalmic Inserts. In: Drug development and industrial pharmacy, 1995, vol. 21, n° 1, p. 1–18. doi: 10.3109/03639049509048094

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0363-9045
551views
2downloads

Technical informations

Creation

14/04/2016 09:12:00

First validation

14/04/2016 09:12:00

Update

15/03/2023 00:18:09

Status update

15/03/2023 00:18:09

Last indexation

31/10/2024 03:15:43
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated