Three word-spotting experiments assessed the role of syllable onsets and offsets in lexical segmentation. Participants detected CVC words embedded initially or finally in bisyllabic nonwords with aligned (CVC.CVC) or misaligned (CV.CCVC) syllabic structure. A misalign- ment between word and syllable onsets (Experiment 1) produced a greater perceptual cost than a misalignment between word and syllable offsets (Experiments 2 and 3). These results suggest that listeners rely on syllable onsets to locate the beginning of words. The implications for theories of lexical access in continuous speech are discussed.