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Scientific article
English

Ruthenium Lewis acid catalyzed asymmetric 1,3-dipolar cycloadditions between N-methylnitrones and enals

Published inSynthesis, vol. 2010, no. 13, p. 2207-2212
Publication date2010
Abstract

N-Methylisoxazolidines are formed in good yields and high regio-, diastereo- and enantioselectivity via asymmetric 1,3-dipolar cycloaddition of nitrones with enals catalyzed by a chiral ruthenium Lewis acid. Electronic effects in the dipole are the key to activation of these substrates for efficient catalysis.

Keywords
  • Asymmetric catalysis
  • Lewis acid
  • Ruthenium
  • N-methyl nitrones
  • 1,3-dipolar cycloaddition
Citation (ISO format)
BADOIU, Andréi, BERNARDINELLI, Gérald Hugues, KUNDIG, Ernst Peter. Ruthenium Lewis acid catalyzed asymmetric 1,3-dipolar cycloadditions between N-methylnitrones and enals. In: Synthesis, 2010, vol. 2010, n° 13, p. 2207–2212. doi: 10.1055/s-0029-1218788
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Article (Published version)
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Identifiers
ISSN of the journal0039-7881
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Creation06/22/2010 8:35:00 AM
First validation06/22/2010 8:35:00 AM
Update time03/14/2023 3:48:53 PM
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