fr
Article scientifique
Anglais

Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers

Publié dansDrug development and industrial pharmacy, vol. 24, no. 12, p. 1113-1128
Date de publication1998
Résumé

The techniques available to prepare biodegradable nanoparticles (nanospheres and nanocapsules) from preformed polymers are reviewed. Although there is abundant literature on this topic, only a few focus on the thorough analysis of preparative procedures. In particular, four techniques are discussed in terms of their technological advantages and drawbacks: emulsification evaporation, solvent displacement, salting-out, and emulsification diffusion. The proposed mechanism of nanoparticle formation for each technique is described from a physicochemical perspective. The effects of preparative variables on nanoparticle size and drug-entrapment efficiency are also discussed.

Mots-clés
  • Nanoparticles
  • Nanospheres
  • Nanocapsules
  • Preparation methods
  • Mechanism of formation
Groupe de recherche
Citation (format ISO)
QUINTANAR GUERRERO, David et al. Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. In: Drug development and industrial pharmacy, 1998, vol. 24, n° 12, p. 1113–1128. doi: 10.3109/03639049809108571
Fichiers principaux (1)
Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal0363-9045
457vues
0téléchargements

Informations techniques

Création05/04/2016 10:55:00
Première validation05/04/2016 10:55:00
Heure de mise à jour15/03/2023 00:16:48
Changement de statut15/03/2023 00:16:48
Dernière indexation16/01/2024 20:37:19
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack