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Title

Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers

Authors
Fessi, Hatem
Published in Drug Development and Industrial Pharmacy. 1998, vol. 24, no. 12, p. 1113-1128
Abstract The techniques available to prepare biodegradable nanoparticles (nanospheres and nanocapsules) from preformed polymers are reviewed. Although there is abundant literature on this topic, only a few focus on the thorough analysis of preparative procedures. In particular, four techniques are discussed in terms of their technological advantages and drawbacks: emulsification evaporation, solvent displacement, salting-out, and emulsification diffusion. The proposed mechanism of nanoparticle formation for each technique is described from a physicochemical perspective. The effects of preparative variables on nanoparticle size and drug-entrapment efficiency are also discussed.
Keywords NanoparticlesNanospheresNanocapsulesPreparation methodsMechanism of formation
Identifiers
PMID: 9876569
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Article (Published version) (1.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Technologie pharmaceutique
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QUINTANAR GUERRERO, David et al. Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. In: Drug Development and Industrial Pharmacy, 1998, vol. 24, n° 12, p. 1113-1128. https://archive-ouverte.unige.ch/unige:82870

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Deposited on : 2016-04-14

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