Scientific article

Apoptosis: bombarding the mitochondria

Published inEssays in biochemistry, vol. 39, p. 41-51
Publication date2003

Mitochondria play a central role in apoptosis triggered by many stimuli. They integrate death signals through Bcl-2 family members and co-ordinate caspase activation through the release of apoptogenic factors that are normally sequestered in the mitochondrial intermembrane space. The release of these proteins is the result of the outer mitochondrial membrane becoming permeable. In addition, mitochondria can initiate apoptosis through the production of reactive oxygen species.

  • Animals
  • Apoptosis
  • Caenorhabditis elegans/metabolism
  • Gene Expression Regulation
  • Mitochondria/metabolism/physiology
  • Models
  • Biological
  • Oxygen/metabolism
  • Proto-Oncogene Proteins c-bcl-2/metabolism
Citation (ISO format)
PARONE, Philippe et al. Apoptosis: bombarding the mitochondria. In: Essays in biochemistry, 2003, vol. 39, p. 41–51.
Main files (1)
Article (Published version)
ISSN of the journal0071-1365

Technical informations

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