en
Scientific article
Letter
English

SimplePhos as efficient ligands for the copper-catalysed kinetic resolution of cyclic vinyloxiranes with grignard reaggents

Published inSynlett, no. 12, p. 1797-1800
Publication date2008
Abstract

Cyclic vinyloxiranes react with Grignard reagents under copper catalysis. Highly efficient kinetic resolution is achieved with the new SimplePhos family of chiral phosphorus ligands. Stereodivergence could be exploited to get either the SN2 or SN2' product with up to 96% ee.

Keywords
  • Epoxides
  • Asymmetric synthesis
  • Grignard reagents
  • Catalysis
  • Copper
Citation (ISO format)
MILLET, Renaud, ALEXAKIS, Alexandre. SimplePhos as efficient ligands for the copper-catalysed kinetic resolution of cyclic vinyloxiranes with grignard reaggents. In: Synlett, 2008, n° 12, p. 1797–1800. doi: 10.1055/s-2008-1077901
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0936-5214
500views
0downloads

Technical informations

Creation06/21/2010 2:45:09 PM
First validation06/21/2010 2:45:09 PM
Update time03/14/2023 3:48:42 PM
Status update03/14/2023 3:48:42 PM
Last indexation01/15/2024 8:29:55 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack