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Title

Sonic hedgehog induces the segregation of patched and smoothened in endosomes

Authors
Incardona, John P.
Roelink, Henk
Published in Current Biology. 2002, vol. 12, no. 12, p. 983-995
Abstract Sonic hedgehog (Shh) signal transduction involves the ligand binding Patched1 (Ptc1) protein and a signaling component, Smoothened (Smo). A select group of compounds inhibits both Shh signaling, regulated by Ptc1, and late endosomal lipid sorting, regulated by the Ptc-related Niemann-Pick C1 (NPC1) protein. This suggests that Ptc1 regulates Smo activity through a common late endosomal sorting pathway also utilized by NPC1. During signaling, Ptc accumulates in endosomal compartments, but it is unclear if Smo follows Ptc into the endocytic pathway.
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PMID: 12123571
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INCARDONA, John P., GRUENBERG, Jean, ROELINK, Henk. Sonic hedgehog induces the segregation of patched and smoothened in endosomes. In: Current Biology, 2002, vol. 12, n° 12, p. 983-995. https://archive-ouverte.unige.ch/unige:82367

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Deposited on : 2016-04-05

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