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Scientific article
English

Sonic hedgehog induces the segregation of patched and smoothened in endosomes

Published inCurrent biology, vol. 12, no. 12, p. 983-995
Publication date2002
Abstract

Sonic hedgehog (Shh) signal transduction involves the ligand binding Patched1 (Ptc1) protein and a signaling component, Smoothened (Smo). A select group of compounds inhibits both Shh signaling, regulated by Ptc1, and late endosomal lipid sorting, regulated by the Ptc-related Niemann-Pick C1 (NPC1) protein. This suggests that Ptc1 regulates Smo activity through a common late endosomal sorting pathway also utilized by NPC1. During signaling, Ptc accumulates in endosomal compartments, but it is unclear if Smo follows Ptc into the endocytic pathway.

Citation (ISO format)
INCARDONA, John P., GRUENBERG, Jean, ROELINK, Henk. Sonic hedgehog induces the segregation of patched and smoothened in endosomes. In: Current biology, 2002, vol. 12, n° 12, p. 983–995. doi: 10.1016/S0960-9822(02)00895-3
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ISSN of the journal0960-9822
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