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Relationship between the swelling process and the release of a water-soluble drug from a compressed swellable-soluble matrix of poly(vinyl alcohol)

Publié dansDrug development and industrial pharmacy, vol. 25, no. 2, p. 169-174
Date de publication1999
Résumé

An attempt was made in this study to relate the release of a highly water-soluble model drug from tablet matrices of poly(vinyl alcohol) (PVAL) with the factors that may affect the release behavior. Swelling was evaluated using a simple projection method. The swollen layer was photographed to monitor its thickness. The polymer and drug dissolution were determined simultaneously by spectrophotometric methods. The resulting change of tablet area showed that the process of swelling occurred in three different stages that were intimately related to polymer dissolution: (a) a rapid initial swelling, resulting in an increased area; (b) a period with an approximately constant area; and (c) a decrease of the tablet area. In spite of the significant dissolution of PVAL during the release process, the thickness of the gel layer gradually increased. Thus, the delivery was governed by the drug concentration gradient along the diffusional path length. The drug release appeared to be controlled by a diffusion process according to Higuchi-type kinetics. The data analysis of drug and polymer profiles confirmed the diffusional mechanism.

Citation (format ISO)
QUINTANAR-GUERRERO, David et al. Relationship between the swelling process and the release of a water-soluble drug from a compressed swellable-soluble matrix of poly(vinyl alcohol). In: Drug development and industrial pharmacy, 1999, vol. 25, n° 2, p. 169–174. doi: 10.1081/DDC-100102157
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ISSN du journal0363-9045
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Création05.04.2016 10:12:00
Première validation05.04.2016 10:12:00
Heure de mise à jour15.03.2023 00:15:12
Changement de statut15.03.2023 00:15:12
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