Synthesis and anti-HIV activity of 3′-deoxy-3′-(N-hydroxyamino) analogues of nucleosides

Tronchet, Jean Marcel Julien; Zsely Schaffter, Martina Maria; Capek, Karel; De Villedon De Naide, Fabienne Odette

doi:10.1016/S0960-894X(00)80464-3

Scientific article

English

Synthesis and anti-HIV activity of 3′-deoxy-3′-(N-hydroxyamino) analogues of nucleosides

ContributorsTronchet, Jean Marcel Julien; Zsely Schaffter, Martina Maria; Capek, Karel; De Villedon De Naide, Fabienne Odette

Published inBioorganic & medicinal chemistry letters, vol. 2, no. 12, p. 1723-1728

Publication date1992

Abstract

3′-Deoxy analogues of thymidine and uridine bearing a 3′-N-alkyl-(or N-aralkyl) -N-hydroxyamino group either on the α or the β face of the furanose ring have been prepared. One of these, exhibited a moderate anti-HIV activity.

Affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

TRONCHET, Jean Marcel Julien et al. Synthesis and anti-HIV activity of 3′-deoxy-3′-(N-hydroxyamino) analogues of nucleosides. In: Bioorganic & medicinal chemistry letters, 1992, vol. 2, n° 12, p. 1723–1728. doi: 10.1016/S0960-894X(00)80464-3

Article (Published version)

Identifiers

PID : unige:82362
DOI : 10.1016/S0960-894X(00)80464-3

Additional URL for this publicationhttp://linkinghub.elsevier.com/retrieve/pii/S0960894X00804643

Journal ISSN0960-894X

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Synthesis and anti-HIV activity of 3′-deoxy-3′-(N-hydroxyamino) analogues of nucleosides

3′-Deoxy analogues of thymidine and uridine bearing a 3′-N-alkyl-(or N-aralkyl) -N-hydroxyamino group either on the α or the β face of the furanose ring have been prepared. One of these, exhibited a moderate anti-HIV activity.

Technical informations