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Scientific article
English

Formation of all-carbon quaternary centers by copper-catalysed asymmetric conjugate addition

Contributors

Alexakis, Alexandre; Vuagnoux-D'Augustin De, Magali; Martin, David; Kehrli, Stefan; Palais, Laetitia; Henon, Hélène; Hawner, Christine

Published in

Chimia, vol. 62, no. 6, p. 461-464

Publication date

2008

Abstract

This mini-review deals with a special, and challenging, aspect of the asymmetric conjugate addition: the formation of all-carbon quaternary centers by reaction with Michael acceptors bearing a polysubstituted unsaturation. Only copper catalysts allow this transformation, along with a careful choice of primary organometallics and chiral ligand. The resulting adducts are useful intermediates for the synthesis of more complex natural products.

Keywords

  • Aluminium
  • Asymmetry
  • Catalysis
  • Conjugate addition
  • Copper
  • Magnesium
  • Zinc

UNIGE affiliation entities

Citation (ISO format)

ALEXAKIS, Alexandre et al. Formation of all-carbon quaternary centers by copper-catalysed asymmetric conjugate addition. In: Chimia, 2008, vol. 62, n° 6, p. 461–464. doi: 10.2533/chimia.2008.461

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0009-4293
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Technical informations

Creation

21/06/2010 14:45:00

First validation

21/06/2010 14:45:00

Update

14/03/2023 15:48:40

Status update

14/03/2023 15:48:40

Last indexation

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