Practical, solvent-free, one-pot synthesis of C2-symmetrical secondary amines

Alexakis, Alexandre; Gille, Segolene; Prian, Fabrice; Rosset, Stéphane; Ditrich, Klaus

doi:10.1016/j.tetlet.2003.12.037

Scientific article

Letter

English

Practical, solvent-free, one-pot synthesis of C2-symmetrical secondary amines

ContributorsAlexakis, Alexandre; Gille, Segolene; Prian, Fabrice; Rosset, Stéphane; Ditrich, Klaus

Published inTetrahedron letters, vol. 45, no. 7, p. 1449-1451

Publication date2004

Abstract

A novel one-pot reductive amination of ketones using the combination Ti(OiPr)4/H2/Pd–C is reported. This practical procedure does not require any solvent, and affords C2-symmetrical secondary amines in high yields and excellent diastereoselectivities. A novel one-pot reductive amination of ketones using the combination Ti(OiPr)4/H2/Pd–C is reported. This practical procedure does not require any solvent and affords C2-symmetrical secondary amines in high yields and excellent diastereoselectivities.

Keywords

Reductive amination
C2-symmetry
Chiral amines
Titanium isopropoxide

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

ALEXAKIS, Alexandre et al. Practical, solvent-free, one-pot synthesis of C2-symmetrical secondary amines. In: Tetrahedron letters, 2004, vol. 45, n° 7, p. 1449–1451. doi: 10.1016/j.tetlet.2003.12.037

Article (Published version)

Identifiers

PID : unige:8212
DOI : 10.1016/j.tetlet.2003.12.037

ISSN of the journal0040-4039

596views

0downloads

Creation06/21/2010 2:44:40 PM

First validation06/21/2010 2:44:40 PM

Update time03/14/2023 3:48:35 PM

Status update03/14/2023 3:48:35 PM

Last indexation01/15/2024 8:29:28 PM

Archive ouverte UNIGE

Practical, solvent-free, one-pot synthesis of C2-symmetrical secondary amines

Technical informations