Scientific Article
previous document  unige:82116  next document
add to browser collection
Title

Maternal Control of Vertebrate Development before the Midblastula Transition : Mutants from the Zebrafish I

Authors
Wagner, Daniel S.
Mintzer, Keith A.
Runke, Greg
Wiemelt, Anthony P.
Mullins, Mary C.
Published in Developmental Cell. 2004, vol. 6, no. 6, p. 771-780
Abstract Maternal factors control development prior to the activation of the embryonic genome. In vertebrates, little is known about the molecular mechanisms by which maternal factors regulate embryonic development. To understand the processes controlled by maternal factors and identify key genes involved, we embarked on a maternal-effect mutant screen in the zebrafish. We identified 68 maternal-effect mutants. Here we describe 15 mutations in genes controlling processes prior to the midblastula transition, including egg development, blastodisc formation, embryonic polarity, initiation of cell cleavage, and cell division. These mutants exhibit phenotypes not previously observed in zygotic mutant screens. This collection of maternal-effect mutants provides the basis for a molecular genetic analysis of the maternal control of embryogenesis in vertebrates
Identifiers
Full text
Citation
(ISO format)
DOSCH, Roland et al. Maternal Control of Vertebrate Development before the Midblastula Transition : Mutants from the Zebrafish I. In: Developmental Cell, 2004, vol. 6, n° 6, p. 771-780. https://archive-ouverte.unige.ch/unige:82116

86 hits

43 downloads

Update

Deposited on : 2016-03-24

Export document
Format :
Citation style :