Maternal Control of Development at the Midblastula Transition and beyond : Mutants from the Zebrafish II

Wagner, Daniel S.; Dosch, Roland; Mintzer, Keith A.; Wiemelt, Anthony P.; Mullins, Mary C.

doi:10.1016/j.devcel.2004.04.001

Scientific article

English

Maternal Control of Development at the Midblastula Transition and beyond : Mutants from the Zebrafish II

Contributors

Wagner, Daniel S.; Dosch, Roland; Mintzer, Keith A.; Wiemelt, Anthony P.; Mullins, Mary C.

Published in

Developmental cell, vol. 6, no. 6, p. 781-790

Publication date

2004

Abstract

Many maternal factors in the oocyte persist in the embryo. They are required to initiate zygotic transcription but also function beyond this stage, where they interact with zygotic gene products during embryonic development. In a four-generation screen in the zebrafish, we identified 47 maternal-effect and five paternal-effect mutants that manifest their phenotypes at the time of, or after, zygotic genome activation. We propagated a subset of 13 mutations that cause developmental arrest at the midblastula transition, defects in cell viability, embryonic morphogenesis, and establishment of the embryonic body plan. This diverse group of mutants, many not previously observed in vertebrates, demonstrates a substantial maternal contribution to the “zygotic” period of embryogenesis and a surprising degree of paternal control. These mutants provide powerful tools to dissect the maternal and paternal control of vertebrate embryogenesis

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

WAGNER, Daniel S. et al. Maternal Control of Development at the Midblastula Transition and beyond : Mutants from the Zebrafish II. In: Developmental cell, 2004, vol. 6, n° 6, p. 781–790. doi: 10.1016/j.devcel.2004.04.001

Article (Published version)

Identifiers

PID : unige:82115
DOI : 10.1016/j.devcel.2004.04.001

Additional URL for this publication

http://linkinghub.elsevier.com/retrieve/pii/S153458070400139X

Journal ISSN

1534-5807

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397downloads

Creation

22/03/2016 09:05:00

First validation

22/03/2016 09:05:00

Update

15/03/2023 00:14:16

Status update

15/03/2023 00:14:16

Last indexation

31/10/2024 03:03:45

Maternal Control of Development at the Midblastula Transition and beyond : Mutants from the Zebrafish II

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation