Diastereoselective β-elimination. Synthesis of chiral alkoxy-allenes

Alexakis, Alexandre; Mangeney, Pierre; Normant, Jean F.

doi:10.1016/S0040-4039(00)98990-1

Scientific article

Letter

English

Diastereoselective β-elimination. Synthesis of chiral alkoxy-allenes

ContributorsAlexakis, Alexandre; Mangeney, Pierre; Normant, Jean F.

Published inTetrahedron letters, vol. 26, no. 35, p. 4197-4200

Publication date1985

Abstract

Chiral-alkoxy-allenes are obtazned by reaction by chiral acetyleric acetals with Grignard reagents in the presence of catalytic amount of copper salt. The crucial step is a highly diastereoselective ß-elimination reaction of the transient alkenyl organometallic species.

Affiliation Not a UNIGE publication

Citation (ISO format)

ALEXAKIS, Alexandre, MANGENEY, Pierre, NORMANT, Jean F. Diastereoselective β-elimination. Synthesis of chiral alkoxy-allenes. In: Tetrahedron letters, 1985, vol. 26, n° 35, p. 4197–4200. doi: 10.1016/S0040-4039(00)98990-1

Article (Published version)

Identifiers

PID : unige:8208
DOI : 10.1016/S0040-4039(00)98990-1

ISSN of the journal0040-4039

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Diastereoselective β-elimination. Synthesis of chiral alkoxy-allenes

Chiral-alkoxy-allenes are obtazned by reaction by chiral acetyleric acetals with Grignard reagents in the presence of catalytic amount of copper salt. The crucial step is a highly diastereoselective ß-elimination reaction of the transient alkenyl organometallic species.

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