Asymmetric cleavage of chiral acetals by R2CuLi,BF3 reagents

Ghribi, A.; Alexakis, Alexandre; Normant, Jean F.

doi:10.1016/0040-4039(84)80013-1

Scientific article

Letter

English

Asymmetric cleavage of chiral acetals by R2CuLi,BF3 reagents

ContributorsGhribi, A.; Alexakis, Alexandre; Normant, Jean F.

Published inTetrahedron letters, vol. 25, no. 29, p. 3083-3086

Publication date1984

Abstract

The title reagents cleave diastereoselectively the acetals derived from various aldehydes and chiral 2–3 butane diol (or higher homologs). This reaction affords an asymetric synthesis of secondary alcohols from an aldehyde and a trivial organolithium reagent.

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

GHRIBI, A., ALEXAKIS, Alexandre, NORMANT, Jean F. Asymmetric cleavage of chiral acetals by R2CuLi,BF3 reagents. In: Tetrahedron letters, 1984, vol. 25, n° 29, p. 3083–3086. doi: 10.1016/0040-4039(84)80013-1

Article (Published version)

Identifiers

PID : unige:8207
DOI : 10.1016/0040-4039(84)80013-1

Journal ISSN0040-4039

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Asymmetric cleavage of chiral acetals by R2CuLi,BF3 reagents

The title reagents cleave diastereoselectively the acetals derived from various aldehydes and chiral 2–3 butane diol (or higher homologs). This reaction affords an asymetric synthesis of secondary alcohols from an aldehyde and a trivial organolithium reagent.

Technical informations