UNIGE document Scientific Article
previous document  unige:82043  next document
add to browser collection

Mitochondrial fission and apoptosis: an ongoing trial

Published in Biochimica et Biophysica Acta. 2006, vol. 1763, no. 5-6, p. 522-530
Abstract Apoptosis is a form of programmed cell death that is essential for the development and tissue homeostasis in all metazoan animals. Mitochondria play a critical role during apoptosis, since the release of pro-apoptogenic proteins from the organelle is a pivotal event in cell death triggered by many cytotoxic stimuli. A striking morphological change occurring during apoptosis is the disintegration of the semi-reticular mitochondrial network into small punctiform organelles. It is only recently that this event has been shown to require the activity of proteins involved in the physiological processes of mitochondrial fission and fusion. Here, we discuss how this mitochondrial morphological transition occurs during cell death and the role that it may have in apoptosis.
Keywords MitochondriaApoptosisFissionFusionCytochrome cMitochondrial membrane permeabilisation
PMID: 16762428
Full text
Article (Published version) (246 Kb) - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
PARONE, Philippe, MARTINOU, Jean-Claude. Mitochondrial fission and apoptosis: an ongoing trial. In: Biochimica et Biophysica Acta, 2006, vol. 1763, n° 5-6, p. 522-530. https://archive-ouverte.unige.ch/unige:82043

152 hits

0 download


Deposited on : 2016-03-22

Export document
Format :
Citation style :