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Title

Time-resolved singlet-oxygen luminescence detection with an efficient and practical semiconductor single-photon detector

Authors
Ke, Damei
Bouilloux, Jordan
Published in Biomedical Optics Express. 2016, vol. 7, no. 1, p. 211
Abstract In clinical applications, such as PhotoDynamic Therapy, direct singlet-oxygen detection through its luminescence in the near-infrared range (1270nm)has been a challenging task due to its low emission probability and the lack of suitable single-photon detectors. Here, we propose a practical set up based on a negative-feadback avalanche diode detector that is a valiable alternative to the current state of the hart for different clinical scenarios, especially where geometric collection efficency is limited (e.g.fiber-based systems, confocal microscopy, scanning systems etc.). The proposed set up is caracterised with Rose Bengal as a standard photosensitizer and it is used to measure the singlet-oxygen quantum yield of a new set of a photosensitizer for site-selective photodynamic therapy.
Keywords Photon countingMedical and biological imagingPhotodynamic therapySpectroscopy, fluorescence and luminescenceTime-resolved imagingPhotodetectorsPhotoluminescenceQuantum detectorsPhotochemistry
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BOSO, Gianluca et al. Time-resolved singlet-oxygen luminescence detection with an efficient and practical semiconductor single-photon detector. In: Biomedical Optics Express, 2016, vol. 7, n° 1, p. 211. https://archive-ouverte.unige.ch/unige:81855

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Deposited on : 2016-03-14

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