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Scientific article
Open access
English

Time-resolved singlet-oxygen luminescence detection with an efficient and practical semiconductor single-photon detector

Published inBiomedical optics express, vol. 7, no. 1, 211
Publication date2016
Abstract

In clinical applications, such as PhotoDynamic Therapy, direct singlet-oxygen detection through its luminescence in the near-infrared range (1270nm)has been a challenging task due to its low emission probability and the lack of suitable single-photon detectors. Here, we propose a practical set up based on a negative-feadback avalanche diode detector that is a valiable alternative to the current state of the hart for different clinical scenarios, especially where geometric collection efficency is limited (e.g.fiber-based systems, confocal microscopy, scanning systems etc.). The proposed set up is caracterised with Rose Bengal as a standard photosensitizer and it is used to measure the singlet-oxygen quantum yield of a new set of a photosensitizer for site-selective photodynamic therapy.

Keywords
  • Photon counting
  • Medical and biological imaging
  • Photodynamic therapy
  • Spectroscopy, fluorescence and luminescence
  • Time-resolved imaging
  • Photodetectors
  • Photoluminescence
  • Quantum detectors
  • Photochemistry
Citation (ISO format)
BOSO, Gianluca et al. Time-resolved singlet-oxygen luminescence detection with an efficient and practical semiconductor single-photon detector. In: Biomedical optics express, 2016, vol. 7, n° 1, p. 211. doi: 10.1364/BOE.7.000211
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Article (Published version)
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Identifiers
ISSN of the journal2156-7085
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