

![]() |
Enantioselective copper-catalyzed conjugate addition to trisubstituted cyclohexenones: construction of stereogenic quaternary centers |
|
Authors | ||
Published in | Angewandte Chemie. 2005, vol. 44, no. 9, p. 1376-1378 | |
Abstract | Trimethyl- and triethylaluminum undergo enantioselective conjugate addition to 3- and 2-substituted cyclohexenones in the presence of catalytic amounts of a Cu salt and a phosphoramidite ligand L* (see scheme). Thus, chiral quaternary centers can be built with up to 96.6 % ee. Functionalized enones lead to bicyclic structures by a subsequent aldol reaction. | |
Keywords | Aluminum — Asymmetric catalysis — Conjugate addition — Enones — Phosphoramidite ligands | |
Identifiers | PMID: 15666416 | |
Full text | ||
Structures | ||
Citation (ISO format) | VUAGNOUX-D'AUGUSTIN DE, Magali, PALAIS, Laetitia, ALEXAKIS, Alexandre. Enantioselective copper-catalyzed conjugate addition to trisubstituted cyclohexenones: construction of stereogenic quaternary centers. In: Angewandte Chemie, 2005, vol. 44, n° 9, p. 1376-1378. doi: 10.1002/anie.200462137 https://archive-ouverte.unige.ch/unige:8176 |