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Scientific article
English

Palladium mediated synthesis of conjugate (E) or (Z) enones and unsymmetrical divinyl ketones. One-pot preparation of Isoegomaketone

Contributors

Jabri, N.; Alexakis, Alexandre; Normant, Jean F.

Published in

Tetrahedron, vol. 42, no. 5, p. 1369-1380

Publication date

1986

Abstract

The palladium (o) catalyzed coupling of acyl halides or anhydrides with alkenyl copper reagents furnishes a,ß ethylenic ketones and a,ß-a,ß' diethylenic ketones in high yield. The substitution pattern of the alkenyl copper reagent, directly obtained by carbocupration of alkynes, is fully retained. Anhydrides of Z-ethylenic acids also retain their Z stereochemistry. ß-halogeno-vinyl ketones react under the above conditions to afford a,ß-?,d dienones. An efficient one-pot synthesis of Z or var epsilon isoegomaketone is reported.

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

JABRI, N., ALEXAKIS, Alexandre, NORMANT, Jean F. Palladium mediated synthesis of conjugate (E) or (Z) enones and unsymmetrical divinyl ketones. One-pot preparation of Isoegomaketone. In: Tetrahedron, 1986, vol. 42, n° 5, p. 1369–1380. doi: 10.1016/S0040-4020(01)87356-7

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0040-4020
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Technical informations

Creation

21/06/2010 14:44:24

First validation

21/06/2010 14:44:24

Update

14/03/2023 15:48:25

Status update

14/03/2023 15:48:25

Last indexation

29/10/2024 15:34:13
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