en
Scientific article
English

Improved biocompatibility of a viscous bioerodible poly(ortho ester) by controlling the environmental pH during degradation

Published inBiomaterials, vol. 21, no. 17, p. 1773-1778
Publication date2000
Abstract

The poly(ortho ester), POE, used in this investigation, is a viscous bioerodible polymer (8 kDa), which rapidly degrades into a triol and an acidic by-product, acetic acid. In order to improve biocompatibility, we have evaluated the addition of various basic excipients, such as sodium acetate, hydroxyapatite, calcium carbonate and magnesium hydroxide, which buffered and neutralized the acidic degradation product and prolonged the polymer lifetime and drug release. This decrease of POE degradation rate results in a decreased rate of formation of the acidic by-product. Similarly, a POE of higher molecular weight (14 kDa) has been tested. Sodium acetate was too hydrophilic to affect the drug release and the biocompatibility of the polymer, whereas the presence of magnesium hydroxide markedly prolonged the drug release and improved the acceptability of the polymer. The increased molecular weight POE did not improve biocompatibility and a similar but delayed, inflammatory reaction was observed.

Keywords
  • Poly(ortho ester)
  • Biocompatibility
  • Degradation
  • PH
  • In situ bu!er system
  • Release Kinetics
  • 5-FU
Citation (ISO format)
ZIGNANI, Monia et al. Improved biocompatibility of a viscous bioerodible poly(ortho ester) by controlling the environmental pH during degradation. In: Biomaterials, 2000, vol. 21, n° 17, p. 1773–1778. doi: 10.1016/s0142-9612(00)00065-x
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0142-9612
488views
2downloads

Technical informations

Creation03/01/2016 12:02:00 PM
First validation03/01/2016 12:02:00 PM
Update time03/15/2023 12:12:21 AM
Status update03/15/2023 12:12:21 AM
Last indexation01/16/2024 8:25:24 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack