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Title

Proteomic analysis of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of retinoblastoma-interacting-zinc-finger protein

Authors
Chambery, Angela
Di Maro, Antimo
Rossi, Mariangela
Abbondanza, Ciro
Moncharmont, Bruno
Malorni, Livia
Cacace, Giuseppina
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Published in Journal of Proteome Research. 2006, vol. 5, no. 5, p. 1176-85
Abstract To identify a growth-promoting activity related to retinoblastoma-interacting-zinc-finger (RIZ) protein, differential protein expression of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of RIZ protein was analyzed by a robust bottom-up mass-spectrometry proteomic approach. Spots corresponding to qualitative and quantitative differences in protein expression have been selected and identified. Some of these proteins have been previously reported as being associated with different types of carcinomas or involved in cell proliferation and differentiation. Knowledge of specific differentially expressed proteins by MCF-7-derived cell lines expressing RIZ different domains will provide the basis for identifying a growth-promoting activity related to RIZ gene products.
Keywords Biomarkers, Tumor/metabolismBreast Neoplasms/metabolism/pathologyCathepsin D/metabolismCell Line, TumorCytoskeleton/metabolismDNA-Binding Proteins/analysis/genetics/metabolismElectrophoresis, Gel, Two-DimensionalEnergy MetabolismFemaleHistone-Lysine N-MethyltransferaseHumansNuclear Proteins/analysis/genetics/metabolismPhosphopyruvate Hydratase/metabolismProtein IsoformsProtein Structure, TertiaryProteomics/methodsRNA/metabolismSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methodsTranscription Factors/analysis/genetics/metabolismTumor Suppressor Proteins/metabolism
Identifiers
PMID: 16674107
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CHAMBERY, Angela et al. Proteomic analysis of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of retinoblastoma-interacting-zinc-finger protein. In: Journal of Proteome Research, 2006, vol. 5, n° 5, p. 1176-85. https://archive-ouverte.unige.ch/unige:81639

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Deposited on : 2016-03-08

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