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The copper-catalyzed asymmetric allylic substitution

Published in Chimia. 2006, vol. 60, no. 3, p. 124-130
Abstract This mini-review discusses the rapidly growing field of asymmetric copper-catalyzed chemistry. Although the allylic substitution has been less studied than the conjugate addition, recent breakthroughs have made this methodology a very valuable synthetic tool. Thus, a primary allylic halide or phosphate reacts with Grignard or diorganozinc reagents to afford the SN' product (or ?-product) in high regio- and enantioselectivities. Besides the results of the authors, we present also other, different approaches to this reaction, with emphasis on the organo-metallic and the type of chiral ligand used.
Keywords AsymmetryCatalysisCopperMagnesiumSubstitutionZinc
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ALEXAKIS, Alexandre et al. The copper-catalyzed asymmetric allylic substitution. In: Chimia, 2006, vol. 60, n° 3, p. 124-130. doi: 10.2533/000942906777674994 https://archive-ouverte.unige.ch/unige:8128

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Deposited on : 2010-06-21

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