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Scientific article
English

Phosphoramidite Ligands in Iridium-Catalyzed Allylic Substitution

Published inChemistry, vol. 12, no. 13, p. 3596-3609
Publication date2006
Abstract

A new phosphoramidite ligand was used in the iridium-catalyzed allylic substitution reaction. This permitted high regio- and enantioselectivities on a wide variety of substrates and nucleophiles. Because of the stereospecificity of the reaction obtained by using branched substrates, a kinetic resolution reaction was attempted. The origin of the impressive efficiency of this ligand in terms of kinetics was explored in detail, as was the role of the substituent in the ortho-position of the amine moiety.

Keywords
  • Allylic substitution
  • Asymmetric catalysis
  • Chiral ligands
  • Iridium
  • Phosphoramidite
Citation (ISO format)
POLET, Damien et al. Phosphoramidite Ligands in Iridium-Catalyzed Allylic Substitution. In: Chemistry, 2006, vol. 12, n° 13, p. 3596–3609. doi: 10.1002/chem.200501180
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ISSN of the journal0947-6539
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