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Scientific article
French

Baisse de la déhydroépiandrostérone avec l'âge : pertinence clinique et intérêt thérapeutique

Published inRevue médicale suisse, vol. 11, no. 459, p. 321-324
Publication date2015
Abstract

Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are the most abundant steroids in humans, but their levels fall with age. This decrease has been associated with several age related diseases such as falls, osteoporosis, depression, atherosclerosis and sexual disorders. Moreover, studies have shown positive effects of DHEA administration on several of these disorders, with a satisfying safety profile. Unfortunately, DHEA has been too frequently mediatized as a "fountain of youths, which was responsible for either inadequate prescription, or prescription refusal. Longer studies in large populations should help to better define indications, treatment modalities and long-term treatment safety.

Keywords
  • Adrenal Insufficiency/blood/diagnosis/drug therapy
  • Aging/blood
  • Dehydroepiandrosterone/blood/therapeutic use
  • Down-Regulation
  • Humans
Citation (ISO format)
SAMARAS, Nikolaos et al. Baisse de la déhydroépiandrostérone avec l’âge : pertinence clinique et intérêt thérapeutique. In: Revue médicale suisse, 2015, vol. 11, n° 459, p. 321–324.
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Article (Published version)
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Identifiers
ISSN of the journal1660-9379
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Creation11/23/2015 2:19:00 PM
First validation11/23/2015 2:19:00 PM
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