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Baisse de la déhydroépiandrostérone avec l’âge : pertinence clinique et intérêt thérapeutique

Samaras, Nikolaos
Published in Revue médicale suisse. 2015, vol. 11, no. 459, p. 321-324
Abstract Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are the most abundant steroids in humans, but their levels fall with age. This decrease has been associated with several age related diseases such as falls, osteoporosis, depression, atherosclerosis and sexual disorders. Moreover, studies have shown positive effects of DHEA administration on several of these disorders, with a satisfying safety profile. Unfortunately, DHEA has been too frequently mediatized as a "fountain of youths, which was responsible for either inadequate prescription, or prescription refusal. Longer studies in large populations should help to better define indications, treatment modalities and long-term treatment safety.
Keywords Adrenal Insufficiency/blood/diagnosis/drug therapyAging/bloodDehydroepiandrosterone/blood/therapeutic useDown-RegulationHumans
PMID: 25845195
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Research group Diabète et régulation des gènes (36)
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SAMARAS, Nikolaos et al. Baisse de la déhydroépiandrostérone avec l’âge : pertinence clinique et intérêt thérapeutique. In: Revue médicale suisse, 2015, vol. 11, n° 459, p. 321-324. https://archive-ouverte.unige.ch/unige:81172

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Deposited on : 2016-03-01

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