en
Scientific article
English

Physical methods for gene transfer: improving the kinetics of gene delivery into cells

Published inAdvanced drug delivery reviews, vol. 57, no. 5, p. 733-753
Publication date2005
Abstract

One factor critical to successful gene therapy is the development of efficient delivery systems. Although advances in gene transfer technology, including viral and non-viral vectors, have been made, an ideal vector system has not yet been constructed. This review describes the basic principles behind various physical methods for gene transfer and assesses the advantages and performance of such approaches, compared to other transfection systems. In particular, the kinetics and efficiency of gene delivery, the toxicity, in vivo feasibility, and targeting ability of different physical methodologies are discussed and evaluated.

Keywords
  • Animals
  • Cell Membrane/genetics/metabolism
  • Chemistry, Physical
  • Drug Delivery Systems/methods/trends
  • Electroporation/methods/trends
  • Genetic Therapy/methods
  • Humans
  • Physicochemical Phenomena
  • Transfection/methods/trends
Citation (ISO format)
MEHIER-HUMBERT, Sophie, GUY, Richard H. Physical methods for gene transfer: improving the kinetics of gene delivery into cells. In: Advanced drug delivery reviews, 2005, vol. 57, n° 5, p. 733–753. doi: 10.1016/j.addr.2004.12.007
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0169-409X
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