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Title

Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery
Authors
Heller, Jorge
Barr, John
Ng, Steve
Shen, Hui-Rong
Gurny, Robert
Schwach, Khadija
Rothen-Weinhold, Alexandra Laurence
van de Weert, Marco
Published in Journal of Controlled Release. 2002, vol. 78, no. 1-3, p. 133-141
Abstract The preparation of drug delivery devices using solventless fabrication procedures is of significant interest and two such procedures are described. In one such procedure, powdered polymer and micronized protein are intimately mixed and then extruded into 1 mm strands that are cut to the desired length. The polymers used were specifically designed to allow extrusion at temperatures where proteins maintain activity in the dry state. In vitro erosion and BSA release show that BSA release and polymer erosion occur concomitantly indicating an erosion-controlled process. There is a lag-time, but that can be eliminated by the addition to the mixture prior to extrusion small amounts of poly(ethylene glycol) or its methoxy derivatives. The lag-time could also be eliminated by using an AB-block copolymer where A is poly(ortho ester) and B is poly(ethylene glycol). Another means of using solventless fabrication methods is to use a semi-solid material into which drugs can be mixed at room temperature and the semi-solid injected. Data on BSA and bupivacaine release are presented.
Keywords Bupivacaine/administration & dosage — Drug Delivery Systems — Polyethylene Glycols/administration & dosage — Polymers/administration & dosage — Serum Albumin — Bovine/administration & dosage
Identifiers
PMID: 11772455
Full text
Article (Published version) (248 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté des sciences / Section des sciences pharmaceutiques
Citation
(ISO format) 		HELLER, Jorge et al. Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery. In: Journal of Controlled Release, 2002, vol. 78, n° 1-3, p. 133-141. https://archive-ouverte.unige.ch/unige:81156

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Deposited on : 2016-03-01

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