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Scientific article
French

Analogues du GLP-1 versus inhibiteurs du SGLT-2 pour les diabétiques de type 2 obèses

Published inRevue médicale suisse, vol. 11, no. 477, p. 1227-1233
Publication date2015
Abstract

Who never had a type 2 obese diabetic patient, treated by several oral antidiabetic drugs and insulin, with consequent weight gain associated with the therapeutic escalation and uncontrolled diabetes? The arrival of GLP-1 agonists and SGLT-2 inhibitors allows to reevaluate the management of these patients, with their favorable effects on glycemic control, weight and the risk of hypoglycemia and their complementary mechanisms to conventional treatments. The vicious cycle of weight gain and increased need of insulin is limited. The choice between these two molecules must be based on several factors (glycemic target, weight, comorbidities, route of administration, side effects, etc.), and the balanced enthusiasm of these new treatments with the insufficient data regarding their long-term safety and their impact on micro- and macrovascular complications.

Keywords
  • Diabetes Mellitus, Type 2/complications/drug therapy
  • Dipeptidyl-Peptidase IV Inhibitors/therapeutic use
  • Glucagon-Like Peptide 1/analogs & derivatives
  • Humans
  • Hypoglycemic Agents/therapeutic use
  • Incretins/therapeutic use
  • Obesity/complications/drug therapy
  • Practice Guidelines as Topic
  • Receptors, Glucagon/agonists
  • Sodium-Glucose Transporter 2/antagonists & inhibitors
Citation (ISO format)
MARQUES, Ana Rita Forte et al. Analogues du GLP-1 versus inhibiteurs du SGLT-2 pour les diabétiques de type 2 obèses. In: Revue médicale suisse, 2015, vol. 11, n° 477, p. 1227–1233.
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ISSN of the journal1660-9379
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Creation11/23/2015 2:08:00 PM
First validation11/23/2015 2:08:00 PM
Update time03/15/2023 12:10:33 AM
Status update03/15/2023 12:10:33 AM
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