Asymmetric conjugate addition of metal alkyl reagents catalyzed by copper complexes with BINPO, a hemilabile P,O-heterobidentate axially chiral ligand

Fuchs, Nicolas; d'Augustin, Magali; Humam, Munir; Alexakis, Alexandre; Taras, Rossana; Gladiali, Serafino

doi:10.1016/j.tetasy.2005.08.041

Scientific article

English

Asymmetric conjugate addition of metal alkyl reagents catalyzed by copper complexes with BINPO, a hemilabile P,O-heterobidentate axially chiral ligand

ContributorsFuchs, Nicolas; d'Augustin, Magali; Humam, Munir; Alexakis, Alexandre; Taras, Rossana; Gladiali, Serafino

Published inTetrahedron: asymmetry, vol. 16, no. 19, p. 3143-3146

Publication date2005

Abstract

We herein report the use of a new class of P,O-bidentate arylphosphine ligand for the asymmetric copper catalyzed conjugate addition of dialkylzinc and trialkylaluminium with the enantiomeric excesses reaching 91% while (R)-muscone was obtained with 77% ee.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

FUCHS, Nicolas et al. Asymmetric conjugate addition of metal alkyl reagents catalyzed by copper complexes with BINPO, a hemilabile P,O-heterobidentate axially chiral ligand. In: Tetrahedron: asymmetry, 2005, vol. 16, n° 19, p. 3143–3146. doi: 10.1016/j.tetasy.2005.08.041

Article (Published version)

Identifiers

PID : unige:8113
DOI : 10.1016/j.tetasy.2005.08.041

Journal ISSN0957-4166

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Asymmetric conjugate addition of metal alkyl reagents catalyzed by copper complexes with BINPO, a hemilabile P,O-heterobidentate axially chiral ligand

We herein report the use of a new class of P,O-bidentate arylphosphine ligand for the asymmetric copper catalyzed conjugate addition of dialkylzinc and trialkylaluminium with the enantiomeric excesses reaching 91% while (R)-muscone was obtained with 77% ee.

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