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Scientific article
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English

Forward-in-Time, Spatially Explicit Modeling Software to Simulate Genetic Lineages Under Selection

Correction

  • The authors have drawn to the attention of the associate editor of the journal errors in their article.
  • DOI : 10.4137/EBO.S39777
  • PMID : 27429546

Contributors

Currat, Mathias; Gerbault, Pascale; Di, Da; Nunes, Jose Manuel; Sanchez-Mazas, Alicia

Published in

Evolutionary bioinformatics online, no. 2, p. 27-39

Publication date

2015

Abstract

SELECTOR is a software package for studying the evolution of multiallelic genes under balancing or positive selection while simulating complex evolutionary scenarios that integrate demographic growth and migration in a spatially explicit population framework. Parameters can be varied both in space and time to account for geographical, environmental, and cultural heterogeneity. SELECTOR can be used within an approximate Bayesian computation estimation framework. We first describe the principles of SELECTOR and validate the algorithms by comparing its outputs for simple models with theoretical expectations. Then, we show how it can be used to investigate genetic differentiation of loci under balancing selection in interconnected demes with spatially heterogeneous gene flow. We identify situations in which balancing selection reduces genetic differentiation between population groups compared with neutrality and explain conflicting outcomes observed for human leukocyte antigen loci. These results and three previously published applications demonstrate that SELECTOR is efficient and robust for building insight into human settlement history and evolution.

Keywords

  • Population genetics
  • Spatially explicit simulation
  • MHC lineages
  • HLA
  • Balancing selection

UNIGE affiliation entities

UNIGE research groups

Funding

Citation (ISO format)

CURRAT, Mathias et al. Forward-in-Time, Spatially Explicit Modeling Software to Simulate Genetic Lineages Under Selection. In: Evolutionary bioinformatics online, 2015, n° 2, p. 27–39. doi: 10.4137/EBO.S33488

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Article (Published version)

Corrections (1)

Corrigendum

Identifiers

Additional URL for this publication

http://www.la-press.com/forward-in-time-spatially-explicit-modeling-software-to-simulate-genet-article-a5417

Journal ISSN

1176-9343
1716views
550downloads

Technical informations

Creation

26/02/2016 10:04:00

First validation

26/02/2016 10:04:00

Update

13/10/2025 21:04:27

Status update

08/08/2025 12:31:00

Last indexation

15/10/2026 22:59:23
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