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Scientific article
Open access
English

Forward-in-Time, Spatially Explicit Modeling Software to Simulate Genetic Lineages Under Selection

Published inEvolutionary bioinformatics online, no. 2, p. 27-39
Publication date2015
Abstract

SELECTOR is a software package for studying the evolution of multiallelic genes under balancing or positive selection while simulating complex evolutionary scenarios that integrate demographic growth and migration in a spatially explicit population framework. Parameters can be varied both in space and time to account for geographical, environmental, and cultural heterogeneity. SELECTOR can be used within an approximate Bayesian computation estimation framework. We first describe the principles of SELECTOR and validate the algorithms by comparing its outputs for simple models with theoretical expectations. Then, we show how it can be used to investigate genetic differentiation of loci under balancing selection in interconnected demes with spatially heterogeneous gene flow. We identify situations in which balancing selection reduces genetic differentiation between population groups compared with neutrality and explain conflicting outcomes observed for human leukocyte antigen loci. These results and three previously published applications demonstrate that SELECTOR is efficient and robust for building insight into human settlement history and evolution.

Keywords
  • Population genetics
  • Spatially explicit simulation
  • MHC lineages
  • HLA
  • Balancing selection
Funding
  • Swiss National Science Foundation - 31003A-144180, 31003A_156853
  • European Commission - BEAN - Bridging the European and Anatolian Neolithic: Demography, Migration, and Lifestyle at the Advent of Civilization [289966]
Citation (ISO format)
CURRAT, Mathias et al. Forward-in-Time, Spatially Explicit Modeling Software to Simulate Genetic Lineages Under Selection. In: Evolutionary bioinformatics online, 2015, p. 27–39. doi: 10.4137/EBO.S33488
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1176-9343
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Technical informations

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