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Title

Enantioselective copper catalysed 1,4-conjugate addition reactions using chiral N-heterocyclic carbenes

Authors
Pytkowicz, Julien
Roland, Sylvain
Mangeney, Pierre
Published in Journal of Organometallic Chemistry. 2005, vol. 690, no. 24-25, p. 5672-5695
Abstract The preparation of a variety of chiral N-heterocyclic carbene (NHC) precursors is described. The relative merits of imidazolinium salts and silver carbenes as NHC precursors are discussed with respect to their synthesis, stability and performance in the copper catalysed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors. Enantioselectivities of up to 93% were achieved using as little as 4% of chiral ligand.
Keywords Imidazolinium saltsSilver(I)Chiral N-heterocyclic carbenesEnantioselectiveCopper catalysedConjugate addition
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WINN, Caroline Louise et al. Enantioselective copper catalysed 1,4-conjugate addition reactions using chiral N-heterocyclic carbenes. In: Journal of Organometallic Chemistry, 2005, vol. 690, n° 24-25, p. 5672-5695. https://archive-ouverte.unige.ch/unige:8109

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Deposited on : 2010-06-21

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