Copper-catalysed asymmetric conjugate addition of aryl aluminium reaggents to trisubstituted enones: construction of aryl-substituted quaternary centers

Hawner, Christine; Li, Kangying; Cirriez, Virginie; Alexakis, Alexandre

doi:10.1002/anie.200803436

Scientific article

English

Copper-catalysed asymmetric conjugate addition of aryl aluminium reaggents to trisubstituted enones: construction of aryl-substituted quaternary centers

ContributorsHawner, Christine; Li, Kangying; Cirriez, Virginie; Alexakis, Alexandre

Published inAngewandte Chemie, vol. 47, no. 43, p. 8211-8214

Publication date2008

Abstract

Novel aryl and alkenyl aluminum reagents are generated through a halogen/Li exchange-Li/Al transmetalation sequence. These aryl alanes are used in the copper-catalyzed asymmetric conjugate addition reaction to a variety of cyclic enones giving chiral aryl-substituted quaternary centers. Both, electron-donating and electron-withdrawing groups give full conversion and very good ee values.

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

HAWNER, Christine et al. Copper-catalysed asymmetric conjugate addition of aryl aluminium reaggents to trisubstituted enones: construction of aryl-substituted quaternary centers. In: Angewandte Chemie, 2008, vol. 47, n° 43, p. 8211–8214. doi: 10.1002/anie.200803436

Article (Published version)

Identifiers

PID : unige:8101
DOI : 10.1002/anie.200803436
PMID : 18814167

ISSN of the journal1433-7851

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Copper-catalysed asymmetric conjugate addition of aryl aluminium reaggents to trisubstituted enones: construction of aryl-substituted quaternary centers

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