Enantioselective addition of aryllithium reagents to aromatic imines mediated by 1,2-diamine ligands

Cabello, Noemi; Kizirian, Jean-Claude; Alexakis, Alexandre

doi:10.1016/j.tetlet.2004.04.100

Scientific article

Letter

English

Enantioselective addition of aryllithium reagents to aromatic imines mediated by 1,2-diamine ligands

ContributorsCabello, Noemi; Kizirian, Jean-Claude; Alexakis, Alexandre

Published inTetrahedron letters, vol. 45, no. 24, p. 4639-4642

Publication date2004

Abstract

A variety of optically enriched amines have been obtained by addition of aryllithium reagents to aromatic imines using N,N'-tetramethylcyclohexane-1,2-diamine as chiral ligands. Enantiomeric excesses up to 90% could be obtained.

Keywords

Diarylmethylamines
Organolithium
Asymmetry
Diamines
Chiral ligands
Addition to imines

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

CABELLO, Noemi, KIZIRIAN, Jean-Claude, ALEXAKIS, Alexandre. Enantioselective addition of aryllithium reagents to aromatic imines mediated by 1,2-diamine ligands. In: Tetrahedron letters, 2004, vol. 45, n° 24, p. 4639–4642. doi: 10.1016/j.tetlet.2004.04.100

Article (Published version)

Identifiers

PID : unige:8096
DOI : 10.1016/j.tetlet.2004.04.100

Journal ISSN0040-4039

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Enantioselective addition of aryllithium reagents to aromatic imines mediated by 1,2-diamine ligands

A variety of optically enriched amines have been obtained by addition of aryllithium reagents to aromatic imines using N,N'-tetramethylcyclohexane-1,2-diamine as chiral ligands. Enantiomeric excesses up to 90% could be obtained.

Technical informations