Asymmetric conjugate addition of diethylzinc to enones with chiral phosphorus ligands derived from TADDOL

Alexakis, Alexandre; Vastra, Johann; Burton, Jonathan; Benhaim, Cyril; Mangeney, Pierre

doi:10.1016/S0040-4039(98)01761-4

Article scientifique

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Asymmetric conjugate addition of diethylzinc to enones with chiral phosphorus ligands derived from TADDOL

Contributeurs/tricesAlexakis, Alexandre; Vastra, Johann; Burton, Jonathan; Benhaim, Cyril; Mangeney, Pierre

Publié dansTetrahedron letters, vol. 39, no. 43, p. 7869-7872

Date de publication1998

Résumé

The asymmetric conjugate addition of diethyl zinc to cyclohexen-2-one, chalcone and benzalacetone was studied with 0.5% copper (II) triflate and 1% chiral phosphorus ligands derived from TADDOL. Among the several ligand tested, the cyclic phosphite obtained with 1S,2R phenylcyclohexanol gave up to 96% ee of conjugate adduct to cyclohexenone.

Structure d'affiliation Pas une publication de l'UNIGE

Citation (format ISO)

ALEXAKIS, Alexandre et al. Asymmetric conjugate addition of diethylzinc to enones with chiral phosphorus ligands derived from TADDOL. In: Tetrahedron letters, 1998, vol. 39, n° 43, p. 7869–7872. doi: 10.1016/S0040-4039(98)01761-4

Article (Published version)

Identifiants

PID : unige:8091
DOI : 10.1016/S0040-4039(98)01761-4

ISSN du journal0040-4039

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Asymmetric conjugate addition of diethylzinc to enones with chiral phosphorus ligands derived from TADDOL

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