First diastereoselective asymmetric carbometallation of chiral vinyl metals

Brasseur, Denis; Rezaei, Hadi; Fuxa, Alain; Alexakis, Alexandre; Mangeney, Pierre; Marek, Ilan; Normant, Jean F.

doi:10.1016/S0040-4039(98)00942-3

Scientific article

Letter

English

First diastereoselective asymmetric carbometallation of chiral vinyl metals

ContributorsBrasseur, Denis; Rezaei, Hadi; Fuxa, Alain; Alexakis, Alexandre; Mangeney, Pierre; Marek, Ilan; Normant, Jean F.

Published inTetrahedron letters, vol. 39, no. 27, p. 4821-4824

Publication date1998

Abstract

Addition of substituted allylzinc reagents to chiral (Z) metallated allyl amines (or aminal) bearing a chiral aromatic moiety is face selective, and delivers ß-methylated amines with good diastereomeric excess.

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

BRASSEUR, Denis et al. First diastereoselective asymmetric carbometallation of chiral vinyl metals. In: Tetrahedron letters, 1998, vol. 39, n° 27, p. 4821–4824. doi: 10.1016/S0040-4039(98)00942-3

Article (Published version)

Identifiers

PID : unige:8090
DOI : 10.1016/S0040-4039(98)00942-3

Journal ISSN0040-4039

563views

0downloads

Creation21/06/2010 14:16:14

First validation21/06/2010 14:16:14

Update time14/03/2023 15:48:04

Status update14/03/2023 15:48:03

Last indexation29/10/2024 15:32:12

Archive ouverte UNIGE

First diastereoselective asymmetric carbometallation of chiral vinyl metals

Addition of substituted allylzinc reagents to chiral (Z) metallated allyl amines (or aminal) bearing a chiral aromatic moiety is face selective, and delivers ß-methylated amines with good diastereomeric excess.

Technical informations