Acceleration of the conjugate addition of diethyl zinc to enones by either Cu(OTf)2 or trivalent phosphorus ligands

Alexakis, Alexandre; Vasta, Johann; Mangeney, Pierre

doi:10.1016/S0040-4039(97)10068-5

Scientific article

Letter

English

Acceleration of the conjugate addition of diethyl zinc to enones by either Cu(OTf)2 or trivalent phosphorus ligands

ContributorsAlexakis, Alexandre; Vasta, Johann; Mangeney, Pierre

Published inTetrahedron letters, vol. 38, no. 44, p. 7745-7748

Publication date1997

Abstract

The conjugate addition of diethyl zinc to enones under copper catalysis occurs well with copper (II) triflate. Other copper salts need a phosphine or phosphite ligand to be efficient. The best combination is copper (II) triflate and triethyl phosphite. A very small amount of copper (II) triflate (0.5%) and triehyl phosphite (1%) are enough for high yields.

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Not a UNIGE publication

Citation (ISO format)

ALEXAKIS, Alexandre, VASTA, Johann, MANGENEY, Pierre. Acceleration of the conjugate addition of diethyl zinc to enones by either Cu(OTf)2 or trivalent phosphorus ligands. In: Tetrahedron letters, 1997, vol. 38, n° 44, p. 7745–7748. doi: 10.1016/S0040-4039(97)10068-5

Article (Published version)

Identifiers

PID : unige:8089
DOI : 10.1016/S0040-4039(97)10068-5

Journal ISSN0040-4039

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Acceleration of the conjugate addition of diethyl zinc to enones by either Cu(OTf)2 or trivalent phosphorus ligands

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