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Diastereoselective synthesis of α-allenic alcohols from propargylic epoxides |
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Published in | Tetrahedron Letters. 1989, vol. 30, no. 18, p. 2387-2390 | |
Abstract | The cuprocatalyzed reaction of a Grignard reagent with propargylic epoxides proceed through an addition-elimination mechanism. By changing the reaction conditions, particularly the halogen atom of RMgX it is possible to control the diastereoselectivity of the reaction. Both diastereoisomers of anf allenic alcohol can thus be obtained at will. | |
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Citation (ISO format) | ALEXAKIS, Alexandre et al. Diastereoselective synthesis of α-allenic alcohols from propargylic epoxides. In: Tetrahedron Letters, 1989, vol. 30, n° 18, p. 2387-2390. https://archive-ouverte.unige.ch/unige:8075 |