Diastereoselective synthesis of α-allenic alcohols from propargylic epoxides

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Title		Diastereoselective synthesis of α-allenic alcohols from propargylic epoxides
Authors		Alexakis, Alexandre Marek, Ilane Mangeney, Pierre Normant, Jean F.
Published in		Tetrahedron Letters. 1989, vol. 30, no. 18, p. 2387-2390
Abstract		The cuprocatalyzed reaction of a Grignard reagent with propargylic epoxides proceed through an addition-elimination mechanism. By changing the reaction conditions, particularly the halogen atom of RMgX it is possible to control the diastereoselectivity of the reaction. Both diastereoisomers of anf allenic alcohol can thus be obtained at will.
Identifiers		DOI: 10.1016/S0040-4039(01)80406-8
Full text		Article (Published version) - Limited access to UNIGE
Citation (ISO format)		ALEXAKIS, Alexandre et al. Diastereoselective synthesis of α-allenic alcohols from propargylic epoxides. In: Tetrahedron Letters, 1989, vol. 30, n° 18, p. 2387-2390. https://archive-ouverte.unige.ch/unige:8075