Enantioselective ortho-lithiation of benzaldehyde chromiumtricarbonyl complex

Alexakis, Alexandre; Kanger, Tonis; Mangeney, Pierre; Rose-Munch, Françoise; Perrotey, Anne; Rose, Eric

doi:10.1016/0957-4166(95)00283-U

Scientific article

English

Enantioselective ortho-lithiation of benzaldehyde chromiumtricarbonyl complex

ContributorsAlexakis, Alexandre; Kanger, Tonis; Mangeney, Pierre; Rose-Munch, Françoise; Perrotey, Anne; Rose, Eric

Published inTetrahedron: asymmetry, vol. 6, no. 9, p. 2135-2138

Publication date1995

Abstract

The asymmetric ortho lithiation of benzaldehyde chromiumtricarbonyl complex is performed by in situ temporary protection of the aldehyde functionality with a chiral amide and BuLi as metallating agent. Reaction with an electrophile followed by acidic hydrolysis leads to the enantiomerically enriched ortho substituted benzaldehyde chromiumtricarbonyl complex.

Affiliation Not a UNIGE publication

Citation (ISO format)

ALEXAKIS, Alexandre et al. Enantioselective ortho-lithiation of benzaldehyde chromiumtricarbonyl complex. In: Tetrahedron: asymmetry, 1995, vol. 6, n° 9, p. 2135–2138. doi: 10.1016/0957-4166(95)00283-U

Article (Published version)

Identifiers

PID : unige:8064
DOI : 10.1016/0957-4166(95)00283-U

ISSN of the journal0957-4166

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Enantioselective ortho-lithiation of benzaldehyde chromiumtricarbonyl complex

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