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Title

Chiral phosphorus ligands for the asymmetric conjugate addition of organocopper reagents

Authors
Frutos, Juan C.
Mangeney, Pierre
Published in Tetrahedron: Asymmetry. 1993, vol. 4, no. 12, p. 2427-2430
Abstract The asymmetric conjugate addition of medium order alkyl cuprate reagents. R5Cu3Li2, to 2-cyclohexen-1-one. 2-cyclopenten-1-one and 2-cyctohepten-1-one, with the help of phosphorus ligand B*, is described. 3-Alkyl substituted cyclohexanones are obtained in essentially optically pure form. The same chiral ligand, associated with CuI, in catalylic amount (10%), allows the asymmetric conjugate addition of Et2Zn to 2-cyclohexen-1-one.
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ALEXAKIS, Alexandre, FRUTOS, Juan C., MANGENEY, Pierre. Chiral phosphorus ligands for the asymmetric conjugate addition of organocopper reagents. In: Tetrahedron: Asymmetry, 1993, vol. 4, n° 12, p. 2427-2430. https://archive-ouverte.unige.ch/unige:8063

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Deposited on : 2010-06-21

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