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Scientific article
English

Chiral phosphorus ligands for the asymmetric conjugate addition of organocopper reagents

Published inTetrahedron: asymmetry, vol. 4, no. 12, p. 2427-2430
Publication date1993
Abstract

The asymmetric conjugate addition of medium order alkyl cuprate reagents. R5Cu3Li2, to 2-cyclohexen-1-one. 2-cyclopenten-1-one and 2-cyctohepten-1-one, with the help of phosphorus ligand B*, is described. 3-Alkyl substituted cyclohexanones are obtained in essentially optically pure form. The same chiral ligand, associated with CuI, in catalylic amount (10%), allows the asymmetric conjugate addition of Et2Zn to 2-cyclohexen-1-one.

Affiliation Not a UNIGE publication
Citation (ISO format)
ALEXAKIS, Alexandre, FRUTOS, Juan C., MANGENEY, Pierre. Chiral phosphorus ligands for the asymmetric conjugate addition of organocopper reagents. In: Tetrahedron: asymmetry, 1993, vol. 4, n° 12, p. 2427–2430. doi: 10.1016/S0957-4166(00)82216-8
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ISSN of the journal0957-4166
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