Asymmetric conjugate addition of diethyl zinc to enones with chiral phosphine ligands

Alexakis, Alexandre; Burton, Jonathan; Vastra, Johann; Mangeney, Pierre

doi:10.1016/S0957-4166(97)00523-5

Scientific article

English

Asymmetric conjugate addition of diethyl zinc to enones with chiral phosphine ligands

ContributorsAlexakis, Alexandre; Burton, Jonathan; Vastra, Johann; Mangeney, Pierre

Published inTetrahedron: asymmetry, vol. 8, no. 24, p. 3987-3990

Publication date1997

Abstract

Chiral bidentate aryl- and alkyl phosphines (0.5%) coordinated to copper(II) triflate (0.5%) are efficient catalysts for the asymmetric conjugate addition of diethyl zinc to cyclohexen-2-one, chalcone and benzalacetone. Among the chiral phosphines tested, (S)-Norphos, (S,S)-Chiraphos and (R)-Prophos gave the best enantiomeric excesses (44%, 44% and 36% respectively).

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Citation (ISO format)

ALEXAKIS, Alexandre et al. Asymmetric conjugate addition of diethyl zinc to enones with chiral phosphine ligands. In: Tetrahedron: asymmetry, 1997, vol. 8, n° 24, p. 3987–3990. doi: 10.1016/S0957-4166(97)00523-5

Article (Published version)

Identifiers

PID : unige:8059
DOI : 10.1016/S0957-4166(97)00523-5

Journal ISSN0957-4166

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Asymmetric conjugate addition of diethyl zinc to enones with chiral phosphine ligands

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