Biphenol-based ligands for Cu-catalyzed asymmetric conjugate addition

Alexakis, Alexandre; Polet, Damien; Benhaim, Cyril; Rosset, Stéphane

doi:10.1016/j.tetasy.2004.05.016

Scientific article

English

Biphenol-based ligands for Cu-catalyzed asymmetric conjugate addition

ContributorsAlexakis, Alexandre; Polet, Damien; Benhaim, Cyril; Rosset, Stéphane

Published inTetrahedron: asymmetry, vol. 15, no. 14, p. 2199-2203

Publication date2004

Abstract

The synthesis and characterization of seven new phosphoramidite ligands are described, as well as their use in copper-catalyzed 1,4-addition of diethylzinc to a wide range of substrates. Enantioselectivities of up to >99.5% are obtained.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

ALEXAKIS, Alexandre et al. Biphenol-based ligands for Cu-catalyzed asymmetric conjugate addition. In: Tetrahedron: asymmetry, 2004, vol. 15, n° 14, p. 2199–2203. doi: 10.1016/j.tetasy.2004.05.016

Article (Published version)

Identifiers

PID : unige:8055
DOI : 10.1016/j.tetasy.2004.05.016

Journal ISSN0957-4166

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Creation21/06/2010 14:15:56

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Biphenol-based ligands for Cu-catalyzed asymmetric conjugate addition

The synthesis and characterization of seven new phosphoramidite ligands are described, as well as their use in copper-catalyzed 1,4-addition of diethylzinc to a wide range of substrates. Enantioselectivities of up to >99.5% are obtained.

Technical informations