Enantioselective copper-catalyzed conjugate addition using chiral diaminocarbene ligands

Guillen, Frédéric; Winn, Caroline Louise; Alexakis, Alexandre

doi:10.1016/S0957-4166(01)00387-1

Scientific article

English

Enantioselective copper-catalyzed conjugate addition using chiral diaminocarbene ligands

ContributorsGuillen, Frédéric; Winn, Caroline Louise; Alexakis, Alexandre

Published inTetrahedron: asymmetry, vol. 12, no. 15, p. 2083-2086

Publication date2001

Abstract

Chiral diaminocarbene ligands, generated by in-situ deprotonation of the corresponding chiral imidazolinium salts, are shown to be efficient ligands in the asymmetric copper-catalyzed 1,4-conjugate addition of diethylzinc to enones, allowing enantiomeric excesses of up to 51% to be achieved.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

GUILLEN, Frédéric, WINN, Caroline Louise, ALEXAKIS, Alexandre. Enantioselective copper-catalyzed conjugate addition using chiral diaminocarbene ligands. In: Tetrahedron: asymmetry, 2001, vol. 12, n° 15, p. 2083–2086. doi: 10.1016/S0957-4166(01)00387-1

Article (Published version)

Identifiers

PID : unige:8050
DOI : 10.1016/S0957-4166(01)00387-1

Journal ISSN0957-4166

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Enantioselective copper-catalyzed conjugate addition using chiral diaminocarbene ligands

Chiral diaminocarbene ligands, generated by in-situ deprotonation of the corresponding chiral imidazolinium salts, are shown to be efficient ligands in the asymmetric copper-catalyzed 1,4-conjugate addition of diethylzinc to enones, allowing enantiomeric excesses of up to 51% to be achieved.

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