Very efficient phosphoramidite ligand for asymmetric iridium-catalyzed allylic alkylation

Alexakis, Alexandre; Polet, Damien

doi:10.1021/ol048607y

Scientific article

Letter

English

Very efficient phosphoramidite ligand for asymmetric iridium-catalyzed allylic alkylation

Contributors

Alexakis, Alexandre; Polet, Damien

Published in

Organic letters, vol. 6, no. 20, p. 3529-3552

Publication date

2004

Abstract

Linear or branched allylic carbonates or acetates undergo enantioselective iridium-catalyzed allylic substitution with sodium malonate. The reaction is wide in scope and affords the branched product in high yield and with high regio- (up to >99:1) and enantioselectivity (up to 98%). Ten aromatic or aliphatic substrates were successfully tested.

UNIGE affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

ALEXAKIS, Alexandre, POLET, Damien. Very efficient phosphoramidite ligand for asymmetric iridium-catalyzed allylic alkylation. In: Organic letters, 2004, vol. 6, n° 20, p. 3529–3552. doi: 10.1021/ol048607y

Article (Published version)

Identifiers

PID : unige:8041
DOI : 10.1021/ol048607y
PMID : 15387540

Journal ISSN

1523-7052

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21/06/2010 14:15:48

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21/06/2010 14:15:48

Update

14/03/2023 15:47:49

Status update

14/03/2023 15:47:49

Last indexation

10/06/2025 21:35:52

Very efficient phosphoramidite ligand for asymmetric iridium-catalyzed allylic alkylation

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation