en
Scientific article
Letter
English

Copper(I) thiolate catalysts in asymmetric conjugate addition reactions

Published inOrganic letters, vol. 6, no. 12, p. 1959-1962
Publication date2004
Abstract

Full conversion and enantioselectivities up to 83% have been obtained in the conjugate addition reactions of diethyl zinc to Michael acceptors catalyzed by well-defined (chiral) copper(I) aminoarenethiolates. Interesting differences between organozinc or Grignard reagents have been found: for cyclic enones R(2)Zn reagents afford better results, whereas earlier work showed that RMgX reagents react more selectively with acyclic enones.

Citation (ISO format)
ARINK, Anne M. et al. Copper(I) thiolate catalysts in asymmetric conjugate addition reactions. In: Organic letters, 2004, vol. 6, n° 12, p. 1959–1962. doi: 10.1021/ol049457u
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ISSN of the journal1523-7052
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