UNIGE document Scientific Article - Letter
previous document  unige:8038  next document
add to browser collection
Title

Tandem Copper-catalyzed enantioselective allylation-metathesis

Authors
Published in Organic Letters. 2002, vol. 4, no. 23, p. 4147-4149
Abstract Grignard reagents undergo enantioselective (up to 86% ee) copper-catalyzed S(N)2' substitution on achiral allylic chlorides. The reaction is wide in scope for both the Grignard reagent and the allylic substrate. The resulting terminal alkene could be submitted to intra- or intermolecular metathesis to afford new chiral synthons. The experimental conditions are compatible with a one-pot overall substitution-metathesis procedure without loss of enantioselectivity.
Identifiers
PMID: 12423108
Full text
Article (Published version) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Citation
(ISO format)
ALEXAKIS, Alexandre, TISSOT-CROSET, Karine. Tandem Copper-catalyzed enantioselective allylation-metathesis. In: Organic Letters, 2002, vol. 4, n° 23, p. 4147-4149. https://archive-ouverte.unige.ch/unige:8038

244 hits

38 downloads

Update

Deposited on : 2010-06-21

Export document
Format :
Citation style :