Enantioselective copper-catalyzed conjugate addition of dialkylzinc to nitro-olefins

Alexakis, Alexandre; Benhaim, Cyril

doi:10.1021/ol0059596

Scientific article

Letter

English

Enantioselective copper-catalyzed conjugate addition of dialkylzinc to nitro-olefins

ContributorsAlexakis, Alexandre; Benhaim, Cyril

Published inOrganic letters, vol. 2, no. 17, p. 2579-2581

Publication date2000

Abstract

The copper-catalyzed asymmetric conjugate addition of dialkylzinc onto various nitro-olefins has been carried out with excellent results. An enantiomeric excess of up to 94% was obtained using 0.5% Cu(OTf)2 and 1% of chiral trivalent phosphorus ligand.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

ALEXAKIS, Alexandre, BENHAIM, Cyril. Enantioselective copper-catalyzed conjugate addition of dialkylzinc to nitro-olefins. In: Organic letters, 2000, vol. 2, n° 17, p. 2579–2581. doi: 10.1021/ol0059596

Article (Published version)

Identifiers

PID : unige:8035
DOI : 10.1021/ol0059596

Journal ISSN1523-7052

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Enantioselective copper-catalyzed conjugate addition of dialkylzinc to nitro-olefins

The copper-catalyzed asymmetric conjugate addition of dialkylzinc onto various nitro-olefins has been carried out with excellent results. An enantiomeric excess of up to 94% was obtained using 0.5% Cu(OTf)2 and 1% of chiral trivalent phosphorus ligand.

Technical informations