Scientific article
OA Policy
English

Anterior cruciate ligament surgery in the rabbit

Published inJournal of orthopaedic surgery and research, vol. 8, no. 1, 27
Publication date2013-08-19
Abstract

Background: Various methods regarding allograft knee replacements have been described. The animal models, which are generally used for this purpose include sheep, dogs, goats, and pigs, and accrue significant costs for study protocols. The authors herein describe an efficient and cost-effective model to study either native or tissue-engineered allografts for anterior cruciate ligament (ACL) replacement in a New Zealand rabbit model with the potential for transgenic and cell migration studies.

Methods: ACL reconstructions were performed in rabbits under general anesthesia. For fresh allograft implantations, two animals were operated in parallel. Each right extensor digitorum longus tendon was harvested and prepared for implantation. After excision of the ACL, tibial and femoral bone tunnels were created to implant each graft in the native ACL position.

Results: During a 2-year period, the authors have successfully undertaken this surgery in 61 rabbits and have not noticed any major complications attributed to this surgical technique. In addition, the authors have observed fast recovery in the animals postoperatively.

Conclusion: The authors recommend this surgical procedure as an excellent model for the study of knee surgery.

Keywords
  • Anesthesia, General / methods
  • Animals
  • Animals, Genetically Modified
  • Anterior Cruciate Ligament / diagnostic imaging
  • Anterior Cruciate Ligament / surgery
  • Anterior Cruciate Ligament Injuries
  • Anterior Cruciate Ligament Reconstruction / methods
  • Disease Models, Animal
  • Male
  • Perioperative Care / methods
  • Rabbits
  • Specimen Handling / methods
  • Tendons / transplantation
  • Tomography, X-Ray Computed
Affiliation entities Not a UNIGE publication
Citation (ISO format)
BACHY, Manon et al. Anterior cruciate ligament surgery in the rabbit. In: Journal of orthopaedic surgery and research, 2013, vol. 8, n° 1, p. 27. doi: 10.1186/1749-799X-8-27
Main files (1)
Article (Published version)
Identifiers
Journal ISSN1749-799X
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252downloads

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Update time19/11/2024 15:14:41
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